This blood vessel normalization results within an improved barrier function on the main one hand – therefore blocking cancer cell dissemination and metastasis – and in improved tumor perfusion on the other hand, which escalates the response of the tumor to chemotherapy. Chloroquine is certainly a well-known medication with an excellent safety profile that is in use since World Battle 2 for the treatment of malaria and certain auto-immune diseases, including arthritis rheumatoid. More recently, chloroquine has been used in anti-malignancy treatment also. Chloroquine blocks autophagy, an activity that tumor cells make use of to survive to anti-cancer treatments.Eisai and Arena statement excellent results from lorcaserin BLOOM-DM trial in obese, overweight diabetics Arena Pharmaceuticals, Inc. and Eisai Inc. Reported today that top-line outcomes from the one-year lorcaserin BLOOM-DM trial demonstrate statistically significant pounds loss in obese and overweight sufferers with type 2 diabetes. In this trial, lorcaserin fulfilled all three co-primary efficacy endpoints. Furthermore, as described below, lorcaserin individuals taking lorcaserin 10 mg twice daily accomplished statistically significant improvements in multiple secondary endpoints, including HbA1c, as compared to patients randomized to placebo.