In order to devise a real way to restart hair cell formation in the adult ear, Bermingham-McDonogh’s group can be studying how locks cells are made to begin with during ear advancement. The initial stage in the normal development of locks cells is named prosensory specification. In the developing embryo, parts of the ear-forming cells are selected to become the inner hearing organs that detect sound and allow for our feeling of balance. This action is comparable to digging the building blocks of a building. All the subsequent, complex methods in the building of the building need a solid base. Related StoriesScalable creation of gene therapy vectors: an interview with Frank UbagsLinkam phases used in the Wolfson Bioimaging Service at the University of Bristol within the endocytic sorting study of Dr Paul VerkadeLiposomal sizing and the Coulter theory: an interview with Professor Melvin E.However, they found that while injection with SERCA2a restored cardiac function, over time the new SERCA2a became dysfunctional. This indicated that something else upstream from SERCA2a was causing the dysfunction in the center. Changwon Kho, PhD and Ah Youthful Lee, PhD, two postdoctorate students in the study of cardiac proteins at Mount Sinai School of Medicine, determined SUMO1 as the regulator of SERCA2a, showing that it improved its function and improved its enzyme and stability activity. Dr. Hajjar and his team studied pet and human models and discovered that when SUMO1 was decreased, SERCA2a became dysfunctional, showing that SUMO1 takes on a protective role. When the team injected SUMO1 as a gene therapy, they discovered that it shielded SERCA2a from the oxidative stresses and dysfunction that are prevalent in heart failing.