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Trigger found for abnormal muscle constrictions in dystonia Dystonia is a neurological disorder seen as a involuntary abnormal muscle mass constrictions. More than 300,000 people in THE UNITED STATES are affected, but the mechanism of abnormal muscle constrictions has not been well understood. Right here, Japanese research group led by Prof Atsushi Nambu and Dr Satomi Chiken of National Institute for Physiological Sciences in Japan, with Dr. Pullanipally Shashidharan of Mt Sinai College of Medicine in USA, has discovered that the reduced activity of the basal ganglia, a right area of the brain structure, is the main cause of abnormal muscle mass constrictions of dystonia using a mouse model.